• Enterococcus faecium TIR-Domain Genes Are Part of a Gene Cluster Which Promotes Bacterial Survival in Blood 

      Wagner, Theresa; James Peter, Jessin Janice; Paganelli, Fernanda; Willems, Rob J.L.; Askarian, Fatemeh; Pedersen, Torunn Annie; Top, Janetta; de Haas, Carla; van strijp, Jos A. G.; Johannessen, Mona; Hegstad, Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-03)
      <i>Enterococcus faecium</i> has undergone a transition to a multidrug-resistant nosocomial pathogen. The population structure of <i>E. faecium</i> is characterized by a sharp distinction of clades, where the hospital-adapted lineage is primarily responsible for bacteremia. So far, factors that were identified in hospital-adapted strains and that promoted pathogenesis of nosocomial <i>E. faecium</i> ...
    • Serine-aspartate-repeat protein D Increases Staphylococcus aureus Virulence and Survival in Blood 

      Askarian, Fatemeh; Uchiyama, Satoshi; Valderrama, J. Andrés; Ajayi, Clement; Sollid, Johanna U. E.; Van Sorge, Nina M.; Nizet, Victor; van strijp, Jos A. G.; Johannessen, Mona (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-17)
      Staphylococcus aureus expresses a panel of cell wall-anchored adhesins, including proteins belonging to the microbial surface components recognizing adhesive matrix molecule (MSCRAMM) family, exemplified by the serine-aspartate repeat protein D (SdrD), which serve key roles in colonization and infection. Deletion of sdrD from S. aureus subsp. aureus strain NCTC8325-4 attenuated bacterial survival ...